RESEARCH INTERESTS

· Self-assembled Nanoporous Membrane and Its Biomedical Applications (Separation, Drug Delivery, and Sensing)

· Soft Template based Nanomaterials Fabrication for Sensing Device

· Microneedle based Biotechnology Including Surgical Tape, Drug Delivery, and Medical Device

· Biomaterials for Tissue Adhesives, Drug Delivery, and Regenerative Medicine

ONGOING PROJECTS

· Worm-inspired Microneedle Adhesive for Wound Healing

· Nanoporous Membrane for Virus Filtration

EDUCATION

Ph. D.

Pohang University of Science & Technology , South Korea ( Polymer Engineering), Advisor: Jin Kon Kim

M. Eng.

Pohang University of Science & Technology , South Korea ( Polymer Engineering), Advisor: Jin Kon Kim

B. Eng.

Kyungpook National University, South Korea, Double Major (Environmental Engineering / Chemical Engineering)

EXPERIENCE

Pusan National University, Korea

Assistant Professor

Sep. 2013 ~ present

Brigham and Women’s Hospital, Harvard Medical School, USA

Postdoctoral Associate (Advisor : Jeffrey M. Karp)

Sep. 2010 ~ Aug. 2013

Pohang University of Science & Technology (POSTECH), Korea

Postdoctoral Associate (Advisor : Jin Kon Kim)

Mar. 2010 ~ Aug. 2010

POSTECH, Korea

Graduate Student Researcher

Mar. 2004 ~ Feb. 2010

POSTECH, Korea

Summer Intern

July 2003 ~ Aug. 2003

Kyungpook National University , Korea

Research Assistant

Jan. 2002 ~ May 2003

PUBLICATIONS

Peer-Reviewed Journal Publications

43. Kim, B., Seong, K.-Y., You, I., Selvaraj, V., Yim, S.-G., O’Cearbhaill, E. D., Jeong, U. & Yang, S. Y. 2018 “Touch-actuated transdermal delivery patch for quantitative skin permeation control”, Sensors and Actuators B: Chemical, vol. 256, pp. 18-26.

42. Sung, J.-E., Lee, H.-A., Kim, J.-E., Yun, W.-B., An, B.-S., Yang, S Y., Kim, D.-S., Lee, C.-Y., Lee, H.-S., Bae, C.-J. & Hwang D.-Y. 2017 “Saponin-enriched extract of Asparagus cochinchinensis alleviates airway inflammation and remodeling in ovalbumin-induced asthma model”, International Journal of Molecular Mecidine, vol. 40, pp. 1365-1376.

41. Lee, E., Kim, D., Yang, S. Y., Oh, J.-W. & Yoon, J. 2017 “Photo-crosslinkable comb-type copolymers bearing a benzophenone moiety for the enhanced swelling kinetics of hydrogels”, Polymer Chemistry, vol. 8, pp. 6786-6794.

40. Seong, K.-Y., Seo, M.-S., Hwang, D. Y., O’Cearbhaill, E. D., Sreenan, S., Karp, J. M. & Yang, S. Y. 2017 “A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin”, Journal of Controlled Release, vol. 256, pp. 48-56.

39. Park, K. H., Seong, K.-Y., Yang, S. Y. & Seo, S. 2017 “Advances in medical adhesives inspired by aquatic organisms' adhesion”, Biomaterials Research, vol. 21, no. 16, pp. 1-9.

38. Lee, G. W., Lee, S., Kim, J. H., Yim, S.-G., Ryu, J., Lee, E., Lee, J., Yoo, S. I. & Yang, S. Y. 2017 “Density-Controlled Freestanding Biodegradable Nanopillar Arrays Patterned via Block Copolymer Micelle Lithography”, Macromolecular Materials and Engineering, vol. 302, pp. 1600361.

37. Hong, S.-H., Lee, J.-E., An, S.-M., Shin, Y. Y., Hwang, D. Y., Yang, S. Y., Cho, S.-K. & An, B.-S. 2017 “Effect of Vitamin D3 on Biosynthesis of Estrogen in Porcine Granulosa Cells via Modulation of Steroidogenic Enzymes”, vol. 33, no. 1, pp. 49-54

36. Kim, H., Kong, W. H., Seong, K.-Y., Sung, D. K., Jeong, H., Kim, J. K., Yang, S. Y. & Hahn, S. K. 2016, “Hyaluronate-Epidermal Growth Factor Conjugate for Skin Wound Healing and Regeneration”, Biomacromolecules, vol. 17, pp. 3694-3705.

35. Seong, K.-Y. & Yang, S. Y. 2016 “바이오마커 검출을 위한 마이크로니들 기반 센서”, The Korean BioChip Society, vol. 11, pp. 4-6.

34. Lee, S., Ongko, A., Kim, H. Y., Yim, S.-G., Jeon, G., Jeong, H. J., Lee, S., Kwak, M & Yang, S. Y. 2016, “Sub-100nm gold nanohole-enhanced Raman scattering on flexible PDMS sheets”, Nanotechnology, vol. 27, pp. 315301.

33. Hong, S.-H., Lee, J.-E., Kim, H. S., Jung, Y.-J., Hwang, D. Y., Lee J. H., Yang, S. Y., Kim, S.-C., Cho, S.-K. & An, B.-S. 2016 “Effect of vitamin D3 on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes”, The Journal of Biomedical Research, vol. 30, no. 3, pp. 203-208.

32. D. Choi, C. E. Park, S. Y. Yang* , H. Kim*, and S. H. Kim* “ Effect of Solvent-Assisted Dispersions of Clay/Epoxy Nanocomposites on Steel Passivation ” Journal of Nanoscience and Nanotechnology 16, 981-986 (Jan. 1, 2016).

31. H. Kim, H. Lee, K.-Y. Seong, E. Lee, S. Y. Yang * and J. Yoon* “ Visible-light-triggered on-demand drug release from hybrid hydrogels and its application in transdermal patches” Advanced Healthcare Materials 4, 2071-2077 (Oct. 7, 2015).

30. E. J. Kang, J. E. Lee, S. M. An, J. H. Lee, H. S. Kwon, B. C. Kim, S. J. Kim, J. M. Kim, D. Y. Hwang, Y. J. Jung, S. Y. Yang , S. C. Kim and B. S. An * “ The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats” International journal of molecular medicine 36, 1151-1158 (Oct. 1, 2015 ) .

29. J. Go, J.-E. Kim, E.-K. Koh, S.-H. Song, J.-E. Seung, C.-K. park, H.-A. Lee, H.-S. Kim, J.-H. Lee, B.-S. An, S. Y. Yang , Y. Lim and D. -Y. Hwang* “ Hepatotoxicity and nephrotoxicity of gallotannin-enriched extract isolated from Galla Rhois in ICR mice ” Laboratory Animal Reasearch 31, 101-110 (Sep. 30, 2015) .

28. E. H. Lee † , S. Y. Yang † , J. M. Jung, J. H. Oh* “ Polydimethylsiloxane-assisted control of platelet attachment for rapid activation ” Digest Journal of Nanomaterials and Biostructures 10, 865-870 (Aug. 6, 2015 ). † Co-first author

27. B. Li, J. Wang, S. Y. Yang , C. Zhou, and M. X. Wu* “Sample-free quantification of blood biomarkers via laser-treated skin” Biomaterials 59, 30-38 (Aug. 1, 2015) .

26. G. Jeon, J. Jung, S. Lee, K.-Y. Seong, D. Y. Hwang, H. S. Kwon, B. C. Kim, J. M. Kim, J. K. Kim*, and S. Y. Yang * “Free-standing Polyimide Nanotips on Substrates for Preparation of Hollow TiO 2 Nanotips” Journal of Nanoscience and Nanotechnology 15, 5207-5210 (Jul. 1, 2015) .

25. K.-Y. Seong, S.-G. Yim, and S. Y. Yang * “Research trends in medical skin patches ” BT News 22, 62-68 (Apr. 15, 2015) . (Review in Korean)

24. S. H. Park, S.-G. Yim, S. Y. Yang, and S. H. Kim* “ 3D Printing Technology for Biomedical Applications” Prospectives of Industrial Chemistry 18,

67-78 (Feb. 15, 2015). (Review in Korean)

23. G. Jeon, J.-S. Moon, S. Lee, J. H. Lee, B.-S. An, D. Y. Hwang, H. S. Kim, Y. J. Jung, J. K. Kim*, and S. Y. Yang * “Individually aligned Tubular ZnO Nanostructures on Solid Substrates” Materials Letters 13, 373-377 (Dec. 15, 2014) .

22. K.-Y. Seong, S. Y. Yang * "Patch-Type Tissue Adhesives for Wet Conditions“ Polymer Science and Technology 25, 417-421 (Oct. 1, 2014). (Review in Korean)

21. M.-H. Kwak, J.-E. Kim, J. Go, E.-K. Koh, S.-H. Song, J.-E. Sung, S. Y. Yang , B.-S. An, Y. J. Jung, Jae-Ho Lee, Y. Lim, D. Y. Hwang* “ Characterization of allergic response induced by repeated dermal exposure of IL-4/Luc/CNS-1 transgenic mice to low dose formaldehyde ” Laboratory Animal Research (Sep. 29, 2014) .

20. Y.J. Lee, J.E. Kim, M.H. Kwak, J. Go, S. Y. Yang , H. S. Kwon, B. C. Kim, J. M. Kim, and D. Y. Hwang “Selenium treatment significantly inhibits tumor necrosis factor ? α ? induced cell death and tau hyperphosphorylation in neuroblastoma cells” Molecular Medicine Reports 10, 1869-1874 (Aug. 26, 2014).

19. G. Jeon, M. Jee, S. Y. Yang , B.-Y. Lee, S. K. Jang*, and J. K. Kim*

“Hierarchically Self-Organized Monolithic Nanoporous Membrane for

Exc ellent Virus Enrichment” ACS Applied Materials & Interfaces 6, 1200-1206 (Jan. 22, 2014).

18. S. R. Shin, B. Aghaei-Ghaerh-Bolagh, T. T. Dang, S. N. Topkaya, X. Gao, S. Y. Yang , S. M. Jung, J. H. Oh, M. R. Dokmeci, X. (Shirley) Tang*, and A. Khademhosseini* Advanced Materials 25, 6385-6391 (Nov.26, 2013).

17. E.-S. Kim, D. S. Jang, S. Y. Yang , M. N. Lee, K. S. Jin, H. J. Cha, J. K. Kim, Y. C. Sung and K. Y. Choi* “Controlled release of human growth hormone fused with a human hybrid Fc fragment through a nanoporous polymer membrane” Nanoscale 5, 4262-4269 (May 21, 2013).

16. S. Y. Yang , E. D. O'Cearbhaill, G. C. Sisk, K. M. Park, W. K. Cho, M. Villiger, B. E. Bouma, B. Pomahac, and J. M. Karp* “A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue” Nature Communications 4, 1702 (Apr. 16, 2013). (This work is selected as Featured Image in Nature Communications main homepage and introduced at Research Highlights in Nature (doi:10.1038/496400d). It is also highlighted as News in Science, Nature Medicine, BBC, Fox News, LA times, National Geographic, NIH Director’s Blog, and so on.

15. S. Y. Yang † , E.-S. Kim † , G. Jeon, K. Y. Choi*, and J. K. Kim* “Enhanced Adhesion of Osteoblastic Cells on Polystyrene Films by Independent Control of Surface Topography and Wettability” Materials Science and Engineering C 33, 1689-1695 (Apr. 1, 2013). † Co-first author

14. W. K. Cho, J. A. Ankrum, D. Guo, S. A. Chester, S. Y. Yang , A. Kashyap, G. A. Campbell, R. J. Wood, R. K. Rijal, R. Karnik, R. Langer* and J. M. Karp* “Microstructured barbs on the North American porcupine quill enable easy tissue penetration” Proc. Natl. Acad. Sci. U.S.A 109, 21289-21294 (Dec. 26, 2012). (This work is selected as Cover Picture ).

13. S. Y. Yang , G. Jeon, and J. K. Kim* “A high density array of free standing alumina nanotubes aligned vertically on solid substrates in a large area” Journal of Materials Chemistry 22, 23017-23021 (Nov. 21, 2012) .

12. C. Xu, Y. C. Poh, I. Roes, E. O’Cearbhaill, M. Matthi, L. Mu, S. Y. Yang , D. Mirand, D. Irimia, J. M. Karp* “A Portable Chemotaxis Platform for Short and Long Term Analysis” PLoS One 7, e44995 (Sep. 17, 2012) .

11. G. Jeon, S. Y. Yang , and J. K. Kim* “Functional nanoporous membranes for drug delivery” Journal of Materials Chemistry 22, 14814-14834 (Aug. 14. 2012) .

10. S. Y. Yang † , S. Son † , S. Jang, H. Kim, G. Jeon, W. J. Kim*, and J. K. Kim* “DNA-Functionalized Nanochannels for SNP Detection” Nano Letters 11, 1032-1035 (Mar. 9. 2012) . † Co-first author

9. G. Jeon, S. Y. Yang , J. Byun, J. K. Kim* “Electrically Actuatable Smart Nanoporous Membrane for Pulsatile Drug Release” Nano Letters 11, 1284-1288 (Mar. 9. 2012) .

8. Y. H. Jang, S. Y. Yang , Y. J. Jang, C. Park, J. K. Kim, and D. H. Kim* “Ultrahigh Density Arrays of Toroidal ZnO Nanostructures by One-Step Cooperative Self-Assembly Processes: Mechanism of Structural Evolution and Hybridization with Au Nanoparticles” Chemistry - A European Journal 17, 2068-2076 (Feb. 11, 2011) .

7. J. K. Kim*, S. Y. Yang , Y. Kim, Y. Lee “Functional Nanomaterials Based on Block Copolymer Self-assembly” Progress in Polymer Science 35, 1325-1349 (Nov. 1, 2010).

6. S. Y. Yang † , J.-A Yang † , E. S. Kim, G. Jeon, E. J. Oh, K. Y. Choi, S. K. Hahn*, and J. K. Kim* “Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels” ACS Nano 4, 3817-3822 (July 27, 2010). † Co-first author (Highlighted in the "Perspective" of the same issue (ACS Nano 4, 3548)).

5. W. Joo, S. Y. Yang , J. K. Kim * , H. Jinnai, “Nanohole Structure in Polystyrene- block -poly(methyl methacrylate) /poly(methyl methacrylate) Mixture Film” Langmuir 24, 12612-12617 (Nov. 4, 2008).

4. S. Y. Yang , J. Park, J. Yoon, M. Ree, S. K. Jang, and J. K. Kim*, “Virus Filtration Membrane prepared by Nanoporous Block Copolymer with dimensional stability under high pressures and excellent solvent resistance” Advanced Functional Materials 18, 1371-1377 (May 9, 2008).

3. E. J. Oh, J. Yang, S. Y. Yang J. K. Kim, S. K. Hahn*, “Drug Delivery Systems for Protein Therapeutics“, Polymer Science and Technology 18, 444-449 (Oct. 1, 2007). (Review in Korean)

2. J. Yoon † , S. Y. Yang † , K. Heo, B. Lee, W.-C. Joo, J. K. Kim * , M. Ree * , “Nondestructive, Quantitative Synchtron Grazing Incidence X-ray Scattering Analysis of Cylindrical Nanostructures in Supported Thin Films”, Journal of Applied Crystallography 40, 305-312 (Apr. 1, 2007). † Co-first author

1. S. Y. Yang , I. Ryu, H. Y. Kim, S. K. Jang * , J. K. Kim * and T. P. Russell, “Nanoporous Membrane with Ultrahigh Selectivity and Flux Suitable for Filtration of Viruses”, Advanced Materials 18, 709-712 (Mar. 17, 2006).

Proceedings of Conferences

3. S. Y. Yang, J.-A Yang, S. K. Hahn, and J. K. Kim, “Controlled Release of Protein Drugs Through the Cylindrical Nanochannel” PMSE Preprint 101, 995 (Aug. 2009).

2. J. I. Lee, S. Y. Yang , J. K. Kim, “Nano-structured Materials Prepared by Block Copolymer Thin Films for Photovoltaic Cells And Virus Filtration” PMSE Preprint 95, 931 (Aug. 2006).

1. J. I. Lee, S. Y. Yang , J. A. Jang, U. Jeong, J. K. Kim, “Nanostructured Materials by Block Copolymer Thin Film” Polymer Preprint 46, 565 (Aug. 2005).

PATENTS AND PATENT APPLICATIONS

14. S. Y. Yang, M. J. Shin and Y. S. Jung “ ULTRASONIC IDENTIFIABLE CATHETER ” South Korea patent application 10-2015-0160777 (Nov. 17, 2015) .

13. S. Y. Yang and K. -Y. Seong “ Continuous manufacturing of needle patches using centrifugal force ” South Korea patent application 10-2015-0089624 (Jun. 24, 2015) .

12. E. -S. Kim, D. S. Jang, S. Y. Yang, K. Y. Choi, Y. C. Chul and J. K. Kim “ Drug delivery System for controlled release of Human Growth Hormone fused with human antibody Fc by using Polymer Membrane ” South Korea patent 10-1356251 (Jan. 21, 2014) .

11. S. Y. Yang and S. Lee “용액 공정 가능한 탄소 동소체를 포함하는 하드 마스크 조성물 ” South Korea patent application 10-2015-0022214 (Feb. 13, 2015) .

10. S. Lee and S. Y. Yang “Method of manufacturing a surface-enhanced raman scattering active substrate” South Korea patent 10-1543538 (Aug. 4, 2015) .

9. S. Y. Yang and S. Lee, “Etching mask, method of manufacturing the etching mask, method of manufacturing of a porous membrane, porous membrane, and blocking mask of fine dust having the porous membrane” South Korea patent application 10-2014-0114033 (Aug. 29, 2014) .

8. Jonghyun Oh, S. Y. Yang , Jinmu Jung “Flexible micro gas sensor using nanostructure array and manufacturing method for the same” South Korea patent application 10-2013-0162500 (Dec. 24, 2013).

7. Jonghyun Oh, S. Y. Yang , Jinmu Jung “Flexible micro gas sensor using carbon nanotubes array and manufacturing method for the same” South Korea patent 10-1510597 (Apr. 2, 2015).

6. S. Y. Yang , E. D. O'Cearbhaill, J. M. Karp, B. Pomahac “Swellable adhesive needles” US patent application 61/759,901 (Feb.1, 2013).

5. J. K. Kim, S. Jang, S. Y. Yang , G, Jeon, W. J. Kim, S. Son, H. Kim “Membrane and method of fabricating the same” South Korea patent application 10-2011-0080828 (Aug. 12, 2011) .

4. S. Y. Yang , J. K. Kim, G, Jeon, J. Byun, J. Y. Sohn, C.-S. Lee, H. J. Kim “Nanoporous membrane responsive to electrical stimulation and method for manufacturing the same” South Korea patent application 10-2011-0063990 (June 29, 2011 ) & US patent application , 13/247,615 (Sep. 28, 2011).

3. S. Y. Yang , J. K. Kim, G, Jeon, J. Byun, J. Y. Sohn, C.-S. Lee, H. J. Kim “Method of manufacturing vertically aligned nanotubes, method of manufacturing sensor structure, and sensor element manufactured thereby” South Korea patent 10-1134184 (Mar. 30, 2012) & US patent 8,377,730 (Feb. 19, 2013 ).

2. S. Y. Yang , J. K. Kim, M. S. Park, I. Ryu, S. K. Jang “Nanoporous membrane, process of fabricating the same and device for controlled release of biopharmaceuticals comprising the same” South Korea patent 10-0964504 (June 10, 2010) & US patent 7,935,416 (May 3, 2011).

1. S. Y. Yang , J. K. Kim, M. S. Park, I. Ryu, S. K. Jang “Nanoporous membrane and process for fabrication of the same” South Korea patent 10-0721430 (May 17, 2007) & US patent 7, 438,193 (Oct. 21, 2008).

PRESENTATIONS (SELECTED)

9. S. Y. Yang , E. D. O'Cearbhaill, G. C. Sisk, K. M. Park, W. K. Cho, M. Villiger, B. E. Bouma, B. Pomahac, and J. M. Karp “A Bio-Inspired Microneedle Adhesive for Skin Graft Fixation”, 2013 MIT Polymer Day , Cambridge, MA, USA (Mar. 2013). (Poster presentation)

8. S. Y. Yang , J.-A Yang, E. S. Kim, G. Jeon, E. J. Oh, K. Y. Choi, S. K. Hahn, and J. K. Kim, “Nanoporous Membrane with Block Copolymer Thin Film for Protein Drug Delivery”, APS 2010 March meeting , Portland, USA (Mar. 2010). (Oral presentation)

7. S. Y. Yang , J. A. Yang, S. K. Hahn and J. K. Kim, “Single File Diffusion of Protein Drugs through Cylindrical Nanochannel”, MRS 2008 fall meeting , Boston, USA (Dec. 2008). (Oral presentation)

6. S. Y. Yang , “Nanoporous Membranes with Ultrahigh Selectivity and Flux Suitable for Filtration of Viruses”, First HOPE Meeting , p53, Tsukuba, Japan (Feb. 2008). (Oral presentation)

5. S. Y. Yang , J. Park, S. K. Jang, J. K. Kim “Nanoporous Membranes for virus filtration with very high flux and selectivity” ECS 211 th meeting , Chicago, USA (May 2007). (Oral presentation)

4. S. Y. Yang , I. Ryu, S. K. Jang, J. K. Kim, T. P. Russell “Nanoporous Membranes for virus filtration with high flux” MRS 2007 spring meeting , San Francisco, USA (Mar. 2007). (Oral presentation)

3. S. Y. Yang , I. Ryu, S. K. Jang and J. K. Kim “Nanoporous Memberanes Using Thin Film of Block Copolymer for Virus Filtration” AsiaNano 2006 , Busan, Korea (Nov. 2006). (Oral presentation)

2. S. Y. Yang , W. Joo, and J. K. Kim “Analysis of Nanoporous Structures in Block Copolymer Thin Films”, Korean institute of metals and materials fall meeting , Jeju island, Korea (Oct. 2006). (Invited talk)

1. S. Y. Yang , I. Ryu, H. Y. Kim, S. K. Jang, and J. K. Kim, “Nanoporous Membrane with Ultrahigh Selectivity and Flux Suitable for Filtration of Viruses”, International Congress on Membranes and Membrane Processes , Seoul, Korea (Aug. 2005). (Poster presentation)

Press

사이언스타임즈 http://www.sciencetimes.co.kr/article.do?atidx=0000069996

한계레 ( 사이언스 온 ) http://scienceon.hani.co.kr/media/93668

Nature: doi:10.1038/496400d

Nature Medicine: doi:10.1038/nm0213-124

Science: http://news.sciencemag.org/sciencenow/2013/04/scienceshot-parasite-inspires-su-1.html?ref=hp

BBC News: http://www.bbc.co.uk/news/health-22164451

Fox News: http://www.foxnews.com/science/2013/04/16/parasitic-worm-inspires-surgical-technique/

LA Times: http://www.latimes.com/news/science/sciencenow/la-sci-sn-spiny-headed-parasitic-worm-skin-graft-bioinspired-20130416,0,7980109.story

National Geographic: http://phenomena.nationalgeographic.com/2013/04/16/parasitic-worm-inspires-better-sticky-medical-tape/

The Scientist Magazine: http://www.the-scientist.com/?articles.view/articleNo/36093/title/Sticking-Power/

NIH Director's blog: http://directorsblog.nih.gov/spiny-worm-inspires-next-gen-band-aid/#more-1247

http://youtu.be/9T18POXn_Rc ( 마이크로바늘을 이용한 조직접착제 동영상 )

http://www.ivanhoe.com/contentclientvideo/MB_videozip/mb3671.mov ( 마이크로바늘 접착제가 신바이오 소재로 소개된 동영상 )